Nuclear translocation of IGF1R by intracellular amphiregulin contributes to the resistance of lung tumour cells to EGFR-TKI.

@article{Guerard2018NuclearTO,
  title={Nuclear translocation of IGF1R by intracellular amphiregulin contributes to the resistance of lung tumour cells to EGFR-TKI.},
  author={Marie Guerard and T. Robin and Pascal Perron and Anne-Sophie Hatat and Laurence David-Boudet and Laetitia Vanwonterghem and Benoit Busser and Jean-Luc Coll and Sylvie Lantu{\'e}joul and B{\'e}atrice Eymin and Amandine Hurbin and Sylvie Gazz{\'e}ri},
  journal={Cancer letters},
  year={2018},
  volume={420},
  pages={146-155}
}
Many Receptor Tyrosine Kinases translocate from the cell surface to the nucleus in normal and pathological conditions, including cancer. Here we report the nuclear expression of insulin-like growth factor-1 receptor (IGF1R) in primary human lung tumours. Using lung cancer cell lines and lung tumour xenografts, we demonstrate that the epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) gefitinib induces the nuclear accumulation of IGF1R in mucinous lung adenocarcinoma by a… CONTINUE READING
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