Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase

@inproceedings{Mllers2014NuclearTO,
  title={Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase},
  author={Erik M{\"u}llers and Helena Silva Cascales and Himjyot Jaiswal and Adrian T Saurin and Arne Lindqvist},
  booktitle={Cell cycle},
  year={2014}
}
Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic inducers, and thus the ability to resume cell division. This permanent cell cycle exit depends on p21, p53, and APC/C(Cdh1). However, when and how permanent cell cycle exit occurs remains unclear. Here, we have investigated the cell cycle response to… CONTINUE READING
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