Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase

@article{Mllers2014NuclearTO,
  title={Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase},
  author={Erik M{\"u}llers and Helena Silva Cascales and Himjyot Jaiswal and A. Saurin and A. Lindqvist},
  journal={Cell Cycle},
  year={2014},
  volume={13},
  pages={2733 - 2743}
}
  • Erik Müllers, Helena Silva Cascales, +2 authors A. Lindqvist
  • Published 2014
  • Biology, Medicine
  • Cell Cycle
  • Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic inducers, and thus the ability to resume cell division. This permanent cell cycle exit depends on p21, p53, and APC/CCdh1. However, when and how permanent cell cycle exit occurs remains unclear. Here, we have investigated the cell cycle response to… CONTINUE READING
    Enter the nucleus to exit the cycle
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    Residual Cdk1/2 activity after DNA damage promotes senescence
    19
    ATM/Wip1 activities at chromatin control Plk1 re‐activation to determine G2 checkpoint duration
    19
    Persistent repair intermediates induce senescence
    11
    New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress
    8
    Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
    7

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