Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer.

@article{Arima2007NuclearTO,
  title={Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer.},
  author={Takashi Arima and Hideki Enokida and Hiroyuki Kubo and Ichiro Kagara and Ryouichirou Matsuda and K. Toki and Hiroaki Nishimura and Takeshi Chiyomaru and Shuichi Tatarano and Toshihiko Idesako and Kenryu Nishiyama and Masayuki Nakagawa},
  journal={Cancer science},
  year={2007},
  volume={98 11},
  pages={
          1720-6
        }
}
A disintegrin and metalloproteases (ADAM) are cell membrane-anchored proteins with potential implications for the metastasis of human cancer cells via cell adhesion and protease activities. In prostate cancer (PC), the ADAM-10 protein showed a nuclear localization whereas in benign prostate hypertrophy (BPH) it was predominantly bound to the cell membrane. We hypothesized that the pathogenesis and progression of PC are attributable to the nuclear translocation of ADAM-10. Immunoblotting… CONTINUE READING
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