Nuclear translocation of β-catenin mediates the parathyroid hormone-induced endothelial-to-mesenchymal transition in human renal glomerular endothelial cells.

@article{Wu2014NuclearTO,
  title={Nuclear translocation of β-catenin mediates the parathyroid hormone-induced endothelial-to-mesenchymal transition in human renal glomerular endothelial cells.},
  author={Min Wu and Ri-ning Tang and Hong Liu and Kun-ling Ma and Lin-Li Lv and Bicheng Liu},
  journal={Journal of cellular biochemistry},
  year={2014},
  volume={115 10},
  pages={1692-701}
}
Emerging evidence shows that increased parathyroid hormone (PTH) accelerates endothelial injury and subsequent organ fibrosis. Although the underlying mechanisms remain largely unknown, the endothelial-to-mesenchymal transition (EndMT) has recently been demonstrated to be a crucial event during fibrotic disorders. Therefore, the present study aimed to investigate whether elevated PTH could induce EndMT in primary human renal glomerular endothelial cells (GECs) and to determine the possible… CONTINUE READING