Nuclear transcription factors that bind to elements of the IL-2 promoter. Induction requirements in primary human T cells.

@article{GranelliPiperno1991NuclearTF,
  title={Nuclear transcription factors that bind to elements of the IL-2 promoter. Induction requirements in primary human T cells.},
  author={Angela Granelli-Piperno and Philip Nolan},
  journal={Journal of immunology},
  year={1991},
  volume={147 8},
  pages={2734-9}
}
Prior studies have identified several elements that contribute to the activity of the IL-2 promoter in the stimulated T cell line, Jurkat. The sites and their corresponding nuclear binding factors include: NF-kappa B, AP-1, AP-3, OCT-1, and NF-AT. The latter "nuclear factor for activated T cells" likely contributes to the tissue specificity of IL-2 gene expression. Using electrophoretic mobility shift assays, we have studied these transcription factors in primary T cells from human blood to… CONTINUE READING