Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA.

@article{Horke2004NuclearTO,
  title={Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA.},
  author={Sven Horke and Kerstin Reumann and Michaela Schweizer and H. Will and Tilman Heise},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 25},
  pages={26563-70}
}
Here we provide evidence for an interaction-dependent subnuclear trafficking of the human La (hLa) protein, known as transient interaction partner of a variety of RNAs. Among these, precursor transcripts of certain RNAs are located in the nucleoplasm or nucleolus. Here we examined which functional domains of hLa are involved in its nuclear trafficking. By using green fluorescent-hLa fusion proteins, we discovered a nucleolar localization signal and demonstrated its functionality in a… CONTINUE READING

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