Nuclear thiol peroxidase as a functional alkyl-hydroperoxide reductase necessary for stationary phase growth of Saccharomyces cerevisiae.

@article{Cha2003NuclearTP,
  title={Nuclear thiol peroxidase as a functional alkyl-hydroperoxide reductase necessary for stationary phase growth of Saccharomyces cerevisiae.},
  author={M K Cha and Y Choi and Seung-Keun Hong and Won-Cheol Kim and Kyoung Tai No and I Kim},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 27},
  pages={24636-43}
}
Yeast nucleus-localized thiol peroxidase (nTPx) was characterized as a functional peroxidase. There are two cysteine residues in nTPx. Replacement of Cys-106 or Cys-111 with serine resulted in a complete loss of thioredoxin-linked peroxidase activity. However, when their activities were measured in terms of the ability to inhibit oxidation of glutamine… CONTINUE READING