Nuclear targeting by the growth factor midkine.


Ligand-receptor internalization has been traditionally regarded as part of the cellular desensitization system. Low-density lipoprotein receptor-related protein (LRP) is a large endocytosis receptor with a diverse array of ligands. We recently showed that LRP binds heparin-binding growth factor midkine. Here we demonstrate that LRP mediates nuclear… (More)


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@article{Shibata2002NuclearTB, title={Nuclear targeting by the growth factor midkine.}, author={Yoshihisa Shibata and Takashi Muramatsu and Makoto Hirai and Tatsuya Inui and Terutoshi Kimura and Hidehiko Saito and Lynn M. McCormick and Guojun Bu and Kenji Kadomatsu}, journal={Molecular and cellular biology}, year={2002}, volume={22 19}, pages={6788-96} }