Nuclear survivin as a biomarker for non-small-cell lung cancer

  title={Nuclear survivin as a biomarker for non-small-cell lung cancer},
  author={Bo Lu and Adriana L. Gonzalez and Pierre P. Massion and Yu Shyr and Bashar Shaktour and David Paul Carbone and Dennis E. Hallahan},
  journal={British Journal of Cancer},
  pages={537 - 540}
Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC. 


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