Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force.

  title={Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force.},
  author={Elizabeth A. Booth and Stephen T. Spagnol and Turi A. Alcoser and Kris Noel Dahl},
  journal={Soft matter},
  volume={11 32},
Progerin is a mutant form of the nucleoskeletal protein lamin A, and its expression results in the rare premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS). Patients with HGPS demonstrate several characteristic signs of aging including cardiovascular and skeletal dysfunction. Cells from HGPS patients show several nuclear abnormalities including aberrant morphology, nuclear stiffening and loss of epigenetic modifications including heterochromatin territories. However, it is… CONTINUE READING
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