Nuclear speckles: a model for nuclear organelles

@article{Lamond2003NuclearSA,
  title={Nuclear speckles: a model for nuclear organelles},
  author={A. Lamond and D. Spector},
  journal={Nature Reviews Molecular Cell Biology},
  year={2003},
  volume={4},
  pages={605-612}
}
Speckles are subnuclear structures that are enriched in pre-messenger RNA splicing factors and are located in the interchromatin regions of the nucleoplasm of mammalian cells. At the fluorescence-microscope level they appear as irregular, punctate structures, which vary in size and shape, and when examined by electron microscopy they are seen as clusters of interchromatin granules. Speckles are dynamic structures, and both their protein and RNA–protein components can cycle continuously between… Expand
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TLDR
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