Nuclear signalling by tumour-associated antigen EpCAM

  title={Nuclear signalling by tumour-associated antigen EpCAM},
  author={Dorothea Maetzel and Sabine Denzel and Brigitte Mack and Martin Canis and Philip Went and Michael Benk and Cuong Kieu and Peer Papior and Patrick A. Baeuerle and Markus Munz and Olivier Gires},
  journal={Nature Cell Biology},
EpCAM was found to be overexpressed on epithelial progenitors, carcinomas and cancer-initiating cells. The role of EpCAM in proliferation, and its association with cancer is poorly explained by proposed cell adhesion functions. Here we show that regulated intramembrane proteolysis activates EpCAM as a mitogenic signal transducer in vitro and in vivo. This involves shedding of its ectodomain EpEX and nuclear translocation of its intracellular domain EpICD. Cleavage of EpCAM is sequentially… CONTINUE READING
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