Nuclear sequestration of beta-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation.

@article{Bguin2006NuclearSO,
  title={Nuclear sequestration of beta-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation.},
  author={Pascal B{\'e}guin and Ramasubbu Narayanan Mahalakshmi and Kazuaki Nagashima and Damian Hwee Kiat Cher and Hiroki Ikeda and Yuichiro Yamada and Yutaka Seino and Walter Hunziker},
  journal={Journal of molecular biology},
  year={2006},
  volume={355 1},
  pages={34-46}
}
Voltage-gated Ca2+ channels (VDCCs) are heteromultimeric proteins that mediate Ca2+ influx into cells upon membrane depolarization. These channels are involved in various cellular events, including gene expression, regulation of hormone secretion and synaptic transmission. Kir/Gem, Rad, Rem, and Rem2 belong to the RGK family of Ras-related small G proteins. RGK proteins interact with the beta-subunits and downregulate VDCC activity. Kir/Gem was proposed to prevent surface expression of… CONTINUE READING

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