Nuclear respiratory factor 1 regulates all ten nuclear-encoded subunits of cytochrome c oxidase in neurons.

@article{Dhar2008NuclearRF,
  title={Nuclear respiratory factor 1 regulates all ten nuclear-encoded subunits of cytochrome c oxidase in neurons.},
  author={Shilpa Dhar and Sakkapol Ongwijitwat and Margaret T. T. Wong-Riley},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 6},
  pages={3120-9}
}
Cytochrome c oxidase (COX) is one of only four bigenomic proteins in mammalian cells, having ten subunits encoded in the nuclear genome and three in the mitochondrial DNA. The mechanism of its bigenomic control is not well understood. The ten nuclear subunits are on different chromosomes, and the possibility of their coordinate regulation by the same transcription factor(s) deserves serious consideration. The present study tested our hypothesis that nuclear respiratory factor 1 (NRF-1) serves… CONTINUE READING