Nuclear receptors versus inflammation: mechanisms of transrepression

@article{Pascual2006NuclearRV,
  title={Nuclear receptors versus inflammation: mechanisms of transrepression},
  author={Gabriel Pascual and Christopher K. Glass},
  journal={Trends in Endocrinology \& Metabolism},
  year={2006},
  volume={17},
  pages={321-327}
}
Inflammation is a beneficial host response to external challenge or cellular injury that leads to the activation of a complex array of inflammatory mediators, finalizing the restoration of tissue structure and function. Although a beneficial response, prolonged inflammation can be detrimental to the host, contributing to the pathogenesis of many disease states. Considerable attention has been focused on the ability of several members of the nuclear receptor superfamily to inhibit… Expand
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The history and current advances in nuclear receptor regulation of inflammation by the crosstalk with AP-1 and NF-κB signaling are examined, focusing on the roles of GR and PPARs. Expand
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References

SHOWING 1-10 OF 67 REFERENCES
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression.
TLDR
The cellular signaling pathways identified as important regulators of inflammation are the signal transduction cascades mediated by the nuclear factor-kappaB and the activator protein-1, which can both be modulated by glucocorticoids. Expand
Nuclear receptor signaling in macrophages.
TLDR
Members of the nuclear receptor superfamily of ligand-dependent transcriptions factors have emerged as key regulators of inflammation and lipid homeostasis in macrophages, and their mechanisms of action should help guide the development of new therapeutic agents useful in the treatment of diseases in which macrophage play critical pathogenic roles. Expand
Molecular Determinants of Crosstalk between Nuclear Receptors and Toll-like Receptors
TLDR
Signals and gene-specific repression of transcriptional responses initiated by engagement of toll-like receptors (TLR) 3, 4, and 9 in macrophages are reported and combinatorial control of homeostasis and immune responses by nuclear receptors is revealed and new approaches for treatment of inflammatory diseases are suggested. Expand
Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.
TLDR
Evidence is presented that the ligand-activated glucocorticoid receptor (GR) is able to repress RelA-mediated activation of the ICAM-1 NF-kappa B site, which highlights a possible molecular mechanism that can explain the antiinflammatory effects of glucoc Corticoid treatment during inflammation. Expand
Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor
TLDR
It is found that most actions of glucocorticoid receptor are exerted in the absence of the DNA‐binding ability of the GR: inhibition of the inflammatory response of locally irritated skin and of the systemic response to lipopolysaccharides. Expand
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
TLDR
It is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B activation in mice and cultured cells, mediated by induction of the IκBα inhibitory protein, which traps activated NF-κB in inactive cytoplasmic complexes. Expand
A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation.
  • S. Ogawa, J. Lozach, +7 authors C. Glass
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
Investigation of endogenous transcriptional programs regulated by N coR in macrophages reveals that NCoR acts as a transcriptional checkpoint for activator protein (AP)-1-dependent gene networks that regulate diverse biological processes including inflammation, cell migration, and collagen catabolism, with loss of N CoR. Expand
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
TLDR
This mechanism provides an explanation for how an agonist-bound nuclear receptor can be converted from an activator of transcription to a promoter-specific repressor of NF-κB target genes that regulate immunity and homeostasis. Expand
Nuclear factor-κB in cancer development and progression
TLDR
NF-κB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. Expand
Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
TLDR
It is shown that the synthetic glucocorticoid dexamethasone induces the transcription of the IκBα gene, which results in an increased rate of Iκbα protein synthesis, which is predicted to markedly decrease cytokine secretion and thus effectively block the activation of the immune system. Expand
...
1
2
3
4
5
...