Nuclear receptors are the major targets of endocrine disrupting chemicals
@article{Toporova2020NuclearRA, title={Nuclear receptors are the major targets of endocrine disrupting chemicals}, author={Lucia Toporova and Patrick Balaguer}, journal={Molecular and Cellular Endocrinology}, year={2020}, volume={502} }
44 Citations
Natural and synthetic retinoid X receptor ligands and their role in selected nuclear receptor action.
- Biology, ChemistryBiochimie
- 2020
Virtual screening of potentially endocrine-disrupting chemicals against nuclear receptors and its application to identify PPARγ-bound fatty acids
- Chemistry, BiologyArchives of toxicology
- 2020
A virtual screening method based on molecular docking for predicting potential endocrine-disrupting chemicals (EDCs) that bind to NRs is proposed and found that the consensus enrichment from multiple structures is better than or comparable to the best enrichment from a single structure.
Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434
- BiologyEndocrine regulations
- 2020
The effect of bisphenols on COUP-TFII, Nurr1, and LRH-1 NRs was investigated for the first time and generally it was observed that BPs provoked any alterations in the expression of the selected NRs in COV434 cells, at specific concentrations and time points they might alter mRNA expression of certain NRs.
Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
- Biology, ChemistryJournal of xenobiotics
- 2022
How orthosteric and allosteric binding sites of the different families of membrane receptors can be targets for man-made hydrophobic molecules (components of plastics, paints, flame retardants, herbicides, pesticides, etc.) is reviewed.
Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
- Biology, ChemistryCells
- 2020
The key features and mechanisms of CAR as a xenobiotic-sensing receptor, species differences and selectivity of CAR ligands, contribution of CAR to regulation hepatic metabolism, and evidence for CAR-dependent EDC action therein are reviewed.
In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors
- BiologyiScience
- 2021
A computational insight into endocrine disruption by polychlorinated biphenyls via non-covalent interactions with human nuclear receptors.
- Biology, ChemistryEcotoxicology and environmental safety
- 2021
Allosteric binding on nuclear receptors: Insights on screening of non-competitive endocrine-disrupting chemicals.
- Biology, ChemistryEnvironment international
- 2021
Health effects associated with phthalate activity on nuclear receptors
- Medicine, BiologyReviews on environmental health
- 2021
This review aims to summarize the known action of phthalates on different nuclear receptors and activate and interfere with the normal function of different peroxisome proliferator-activated receptors, receptors that have critical roles in lipid metabolism and energy homeostasis.
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