Nuclear receptors are the major targets of endocrine disrupting chemicals

@article{Toporova2020NuclearRA,
  title={Nuclear receptors are the major targets of endocrine disrupting chemicals},
  author={Lucia Toporova and Patrick Balaguer},
  journal={Molecular and Cellular Endocrinology},
  year={2020},
  volume={502}
}
Virtual screening of potentially endocrine-disrupting chemicals against nuclear receptors and its application to identify PPARγ-bound fatty acids
TLDR
A virtual screening method based on molecular docking for predicting potential endocrine-disrupting chemicals (EDCs) that bind to NRs is proposed and found that the consensus enrichment from multiple structures is better than or comparable to the best enrichment from a single structure.
Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434
TLDR
The effect of bisphenols on COUP-TFII, Nurr1, and LRH-1 NRs was investigated for the first time and generally it was observed that BPs provoked any alterations in the expression of the selected NRs in COV434 cells, at specific concentrations and time points they might alter mRNA expression of certain NRs.
Membrane Hormone Receptors and Their Signaling Pathways as Targets for Endocrine Disruptors
TLDR
How orthosteric and allosteric binding sites of the different families of membrane receptors can be targets for man-made hydrophobic molecules (components of plastics, paints, flame retardants, herbicides, pesticides, etc.) is reviewed.
Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
TLDR
The key features and mechanisms of CAR as a xenobiotic-sensing receptor, species differences and selectivity of CAR ligands, contribution of CAR to regulation hepatic metabolism, and evidence for CAR-dependent EDC action therein are reviewed.
Health effects associated with phthalate activity on nuclear receptors
TLDR
This review aims to summarize the known action of phthalates on different nuclear receptors and activate and interfere with the normal function of different peroxisome proliferator-activated receptors, receptors that have critical roles in lipid metabolism and energy homeostasis.
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