Nuclear receptors are the major targets of endocrine disrupting chemicals

@article{Toporova2020NuclearRA,
  title={Nuclear receptors are the major targets of endocrine disrupting chemicals},
  author={Lucia Toporova and Patrick Balaguer},
  journal={Molecular and Cellular Endocrinology},
  year={2020},
  volume={502}
}
Endocrine disrupting chemicals (EDCs) are exogenous substances that are suspected to cause adverse effects in the endocrine system mainly by acting through their interaction with nuclear receptors such as the estrogen receptors α and β (ERα and ERβ), the androgen receptor (AR), the pregnan X receptor (PXR), the peroxisome proliferator activated receptors α and γ (PPARα, PPARγ) and the thyroid receptors α and β (TRα and TRβ). More recently, the retinoid X receptors (RXRα, RXRβ and RXRγ), the… 
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Natural and synthetic retinoid X receptor ligands and their role in selected nuclear receptor action.
TLDR
This article summarizes both naturally occurring and synthetic ligands for nuclear retinoid X receptors and describes, predominantly in mammals, their role in molecular mechanisms within the cells, with a focus on triorganotin compounds.
Virtual screening of potentially endocrine-disrupting chemicals against nuclear receptors and its application to identify PPARγ-bound fatty acids
TLDR
A virtual screening method based on molecular docking for predicting potential endocrine-disrupting chemicals (EDCs) that bind to NRs is proposed and found that the consensus enrichment from multiple structures is better than or comparable to the best enrichment from a single structure.
Effect of selected bisphenol derivatives on nuclear receptor expression in ovarian cell line COV434
TLDR
The effect of bisphenols on COUP-TFII, Nurr1, and LRH-1 NRs was investigated for the first time and generally it was observed that BPs provoked any alterations in the expression of the selected NRs in COV434 cells, at specific concentrations and time points they might alter mRNA expression of certain NRs.
Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
TLDR
The key features and mechanisms of CAR as a xenobiotic-sensing receptor, species differences and selectivity of CAR ligands, contribution of CAR to regulation hepatic metabolism, and evidence for CAR-dependent EDC action therein are reviewed.
In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors
TLDR
RNA-seq analysis provided no evidence that some pesticides elicit a cellular response, which sometimes interferes with TH signaling, and their neurodevelopmental toxicity in mammals cannot be explained by an alteration of the response to TH.
A computational insight into endocrine disruption by polychlorinated biphenyls via non-covalent interactions with human nuclear receptors.
TLDR
This computational study suggests that PCBs may cause endocrine disruption via formation of non-covalent interactions with androgen, estrogen, glucocorticoid and thyroid hormone receptors.
Allosteric binding on nuclear receptors: Insights on screening of non-competitive endocrine-disrupting chemicals.
TLDR
This work systematically summarized the allosteric sites and underlying mechanisms based on existing studies, mainly regarding drugs belonging to the PPCP class, to drive high-throughput and accurate screening of potential EDCs with non-competitive effects.
Health effects associated with phthalate activity on nuclear receptors
TLDR
This review aims to summarize the known action of phthalates on different nuclear receptors and activate and interfere with the normal function of different peroxisome proliferator-activated receptors, receptors that have critical roles in lipid metabolism and energy homeostasis.
Perfluorinated Iodine Alkanes Induce Tissue-Specific Expression of Estrogen Receptor and Its Phosphorylation
Abstract Understanding the tissue-specific regulation of environmental endocrine disrupting chemicals (EDCs) on the expression and phosphorylation of estrogen receptors (ERs) is essential to fully…
Theoretical study on endocrine disrupting effects of polychlorinated dibenzo‐p‐dioxins using molecular docking simulation
TLDR
Supporting evidence is provided that PCDD molecules may interfere with the endocrine system via binding interactions with some vital amino acid residues in the binding pockets of AR, ERs, GRs and TRs.
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