Nuclear receptors and lipid physiology: opening the X-files.

@article{Chawla2001NuclearRA,
  title={Nuclear receptors and lipid physiology: opening the X-files.},
  author={Ajay Chawla and Joyce J. Repa and Ronald M Evans and David J Mangelsdorf},
  journal={Science},
  year={2001},
  volume={294 5548},
  pages={1866-70}
}
Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only nutritionally important but serve as precursors for ligands that bind to receptors in the nucleus. To become biologically active, these lipids must first be absorbed by the intestine and transformed by metabolic enzymes before they are delivered to their sites of action in the body. Ultimately, the lipids must be eliminated to maintain a normal physiological state. The need to coordinate this… CONTINUE READING
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