Nuclear receptors and endobiotics glucuronidation: the good, the bad, and the UGT.

@article{Bigo2013NuclearRA,
  title={Nuclear receptors and endobiotics glucuronidation: the good, the bad, and the UGT.},
  author={Cyril Bigo and Sarah E Caron and Am{\'e}lie Dallaire-Th{\'e}roux and Olivier Barbier},
  journal={Drug metabolism reviews},
  year={2013},
  volume={45 1},
  pages={34-47}
}
The recent progresses in molecular biology and pharmacology approaches allowed the characterization of a series of nuclear receptors (NRs) as efficient regulators of uridine diphosphate glucuronosyltransferase (UGT) genes activity. These regulatory processes ensure an optimized UGT expression in response to specific endo- and/or exogenous stimuli. Many of these NRs are activated by endobiotics that also are substrates for UGTs. Thus, by activating their receptors, these endogenous substances… CONTINUE READING

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