Nuclear receptors and chromatin: an inducible couple.

  title={Nuclear receptors and chromatin: an inducible couple.},
  author={Raffaella Maria Gadaleta and Luca Magnani},
  journal={Journal of molecular endocrinology},
  volume={52 2},
The nuclear receptor (NR) family comprises 48 transcription factors (TFs) with essential and diverse roles in development, metabolism and disease. Differently from other TFs, NRs engage with well-defined DNA-regulatory elements, mostly after ligand-induced structural changes. However, NR binding is not stochastic, and only a fraction of the cognate… CONTINUE READING