Nuclear receptors, inflammation, and liver disease: insights for cholestatic and fatty liver diseases.

@article{Arrese2010NuclearRI,
  title={Nuclear receptors, inflammation, and liver disease: insights for cholestatic and fatty liver diseases.},
  author={Marco Arrese and Saul J Karpen},
  journal={Clinical pharmacology and therapeutics},
  year={2010},
  volume={87 4},
  pages={
          473-8
        }
}
Members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors are players of substantial relevance in the regulation of hepatic gene expression. NRs direct normal physiology and metabolism, adaptations to liver disease, and responses to inflammation and toxins.They also contribute to the regenerative response. In this review, we summarize currently available experimental and clinical data, focusing on the role of NRs in cholestasis and nonalcoholic fatty liver… CONTINUE READING

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