Nuclear receptor structure: implications for function.

  title={Nuclear receptor structure: implications for function.},
  author={David L. Bain and Aaron F Heneghan and Keith D Connaghan-Jones and Michael T. Miura},
  journal={Annual review of physiology},
Small lipophilic molecules such as steroidal hormones, retinoids, and free fatty acids control many of the reproductive, developmental, and metabolic processes in eukaryotes. The mediators of these effects are nuclear receptor proteins, ligand-activated transcription factors capable of regulating the expression of complex gene networks. This review addresses the structure and structural properties of nuclear receptors, focusing on the well-studied ligand-binding and DNA-binding domains as well… CONTINUE READING