Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home?

@article{Ory2004NuclearRS,
  title={Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home?},
  author={Daniel S Ory},
  journal={Circulation research},
  year={2004},
  volume={95 7},
  pages={660-70}
}
Cholesterol is essential for all mammalian cells. Cellular cholesterol requirements are met through de novo synthesis and uptake of plasma lipoproteins, homeostatic responses that are transcriptionally regulated by the sterol regulatory element-binding proteins (SREBPs). To prevent cytotoxicity attributable to accumulation of excess cholesterol, liver X receptors (LXRs) and the farnesoid X receptor (FXR), together with other members of the nuclear receptor superfamily, promote the storage… CONTINUE READING

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