Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression.

@article{Huss1998NuclearRI,
  title={Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression.},
  author={Janice M. Huss and Charles B. Kasper},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 26},
  pages={16155-62}
}
Many genes of the cytochrome P450 3A (CYP3A) subfamily, including several human and rat isoforms, are inducible by glucocorticoids. In the rat CYP3A23 gene, a 110-base pair segment of the proximal 5'-flanking region mediates dexamethasone activation. Three binding sites (DexRE-1, DexRE-2, and Site A), identified by DNase I footprinting analysis, were characterized for their relative contribution to both basal activity and dexamethasone inducibility. Site-directed mutagenesis of DexRE-1 (-144 to… CONTINUE READING

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