Nuclear receptor coactivators and corepressors.

  title={Nuclear receptor coactivators and corepressors.},
  author={K B Horwitz and Twila A. Jackson and David L. Bain and Jennifer K Richer and Glenn S Takimoto and Lin Tung},
  journal={Molecular endocrinology},
  volume={10 10},
The nuclear receptors belong to a superfamily of proteins, many of which are ligand-regulated, that bind to specific DNA sequences and control specific gene transcription. Recent data show that, in addition to contacting the basal transcription machinery directly, nuclear receptors inhibit or enhance transcription by recruiting an array of coactivator or corepressor proteins to the transcription complex. In this review we define the properties of these putative coregulatory factors; we describe… CONTINUE READING

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