Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation.

Abstract

Uterine receptivity to embryo implantation is coordinately regulated by 17β-estradiol (E(2)) and progesterone (P(4)). Although increased E(2) sensitivity causes infertility, the mechanisms underlying the modulation of E(2) sensitivity are unknown. We show that nuclear receptor coactivator-6 (NCOA6), a reported coactivator for estrogen receptor α (ER… (More)
DOI: 10.1016/j.devcel.2012.09.002

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