Nuclear receptor PXR, transcriptional circuits and metabolic relevance.

  title={Nuclear receptor PXR, transcriptional circuits and metabolic relevance.},
  author={Chibueze A Ihunnah and Mengxi Jiang and Wen Xie},
  journal={Biochimica et biophysica acta},
  volume={1812 8},
The pregnane X receptor (PXR, NR1I2) is a ligand activated transcription factor that belongs to the nuclear hormone receptor (NR) superfamily. PXR is highly expressed in the liver and intestine, but low levels of expression have also been found in many other tissues. PXR plays an integral role in xenobiotic and endobiotic metabolism by regulating the expression of drug-metabolizing enzymes and transporters, as well as genes implicated in the metabolism of endobiotics. PXR exerts its… CONTINUE READING