Nuclear protein matrix: association with newly synthesized DNA.

  title={Nuclear protein matrix: association with newly synthesized DNA.},
  author={Ronald Berezney and D S Coffey},
  volume={189 4199},
The residual structural framework of the cell nucleus termed the nuclear protein matrix, is associated with newly synthesized DNA in regenerating rat liver. One minute after rats are injected with [3-H] thymidine, more than 90 percent of the total tritium in nuclear DNA is associated with the matrix DNA although this DNA comprises only 25 percent of the total nuclear DNA. In contrast, the bulk DNA, 75 percent of total nuclear DNA, contains less than 8 percent of the total labeled DNA. The… CONTINUE READING

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