Nuclear protein kinase C-delta: a possible check-point of cell cycle progression.

  title={Nuclear protein kinase C-delta: a possible check-point of cell cycle progression.},
  author={Marco Marchisio and Valeria Bertagnolo and P Lanuti and Anna Rita Gaspari and Maya Paludi and Fausta Ciccocioppo and Eva Ercolino and Adriana Bascelli and Amelia Cataldi and Sebastian{\'o} Miscia},
  journal={International journal of immunopathology and pharmacology},
  volume={19 2},
Protein kinase Cs (PKCs) belong to a serine/threonine kinase family, ubiquitously expressed and claimed to be involved in physiological processes including apoptosis, cell growth and differentiation. The question of the subcellular localization and activity of PKCs remains to be clarified. Here we report that nuclear PKC-delta cooperates to regulate the S-G2/M phase transition of cell cycle, apparently being associated to chromosome condensation and alignment on the metaphase plate. 

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