Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia.

@article{Roberts2013NuclearPD,
  title={Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia.},
  author={Mark A.J. Roberts and Amy Chadburn and Shuo Nan Ma and Elizabeth Hyjek and Loann C Peterson},
  journal={American journal of clinical pathology},
  year={2013},
  volume={139 2},
  pages={210-9}
}
Waldenström macroglobulinemia (WM) is characterized by monoclonal gammopathy, usually IgM, in association with lymphoplasmacytic lymphoma (LPL). Little is known of the expression of nuclear proteins involved in B-cell development in LPL/WM. In this study, the expression patterns of PAX5/BSAP, MUM1/IRF4, and PRDM1/BLIMP1 were analyzed in plasma cells and lymphocytes in 29 cases of newly diagnosed LPL/WM by double immunohistochemical staining with CD138 and CD22. These patterns were compared with… CONTINUE READING
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