Nuclear processing and export of microRNAs in Arabidopsis.

@article{Park2005NuclearPA,
  title={Nuclear processing and export of microRNAs in Arabidopsis.},
  author={Mee Yeon Park and Gang Wu and Alfredo Gonzalez-Sulser and Herv{\'e} Vaucheret and R Scott Poethig},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 10},
  pages={3691-6}
}
In mammalian cells, the nuclear export receptor, Exportin 5 (Exp5), exports pre-microRNAs (pre-miRNAs) as well as tRNAs into the cytoplasm. In this study, we examined the function of HASTY (HST), the Arabidopsis ortholog of Exp5, in the biogenesis of miRNAs and tRNAs. In contrast to mammals, we found that miRNAs exist as single-stranded 20- to 21-nt molecules in the nucleus in Arabidopsis. This observation is consistent with previous studies indicating that proteins involved in miRNA biogenesis… CONTINUE READING
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  • A. Telfer, K. M. Bollman, R. S. Poethig
  • 1997

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