Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions

Abstract

Astrocytes modulate neuronal activity and inhibit regeneration. We show that cleaved p75 neurotrophin receptor (p75NTR) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of transforming growth factor (TGF)-β signaling. Cleaved p75NTR interacts with nucleoporins to promote… (More)
DOI: 10.1038/nn.4054