Nuclear phosphatase PPM1G in cellular survival and neural development

@article{Foster2013NuclearPP,
  title={Nuclear phosphatase PPM1G in cellular survival and neural development},
  author={W. Foster and Adam D Langenbacher and C. Gao and Jau-Nian Chen and Yibin Wang},
  journal={Developmental Dynamics},
  year={2013},
  volume={242}
}
Background: PPM1G is a nuclear localized serine/threonine phosphatase implicated to be a regulator of chromatin remodeling, mRNA splicing, and DNA damage. However, its in vivo function is unknown. Results: Here we show that ppm1g expression is highly enriched in the central nervous system during mouse and zebrafish development. ppm1g−/− mice were embryonic lethal with incomplete penetrance after E12.5. Rostral defects, including neural tube and craniofacial defects were observed in ppm1g… Expand
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