Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.

@article{Frenoux2004NuclearOR,
  title={Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.},
  author={J-M Frenoux and Patrick Vernet and David H. Volle and Aurore Britan and Fabrice Saez and Ayhan Kocer and Joelle Henry-Berger and David J Mangelsdorf and J-M A Lobaccaro and Jo{\"e}l R. Drevet},
  journal={Journal of molecular endocrinology},
  year={2004},
  volume={33 2},
  pages={361-75}
}
In this study we looked at the epididymides and spermatozoa of mice knocked-out for nuclear oxysterol receptors (LXR). We have shown that LXR-deficient mice exhibited upon ageing a severe disruption of their caput epididymides associated with abnormal accumulation of neutral lipids. The epididymis defaults were correlated with sperm head fragility and infertility. In agreement with the observed caput defect in transgenic animals in which both LXRalpha and LXRbeta isoforms were disrupted, we… CONTINUE READING