Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front.

@article{Brabletz1998NuclearOO,
  title={Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front.},
  author={T. Brabletz and Andreas Jung and Klaus Hermann and Klaus Guenther and Werner Hohenberger and Thomas W. Kirchner},
  journal={Pathology, research and practice},
  year={1998},
  volume={194 10},
  pages={701-4}
}
Sixty to eighty percent of all colorectal cancers are characterized by mutations in the APC tumor suppressor gene. Recently, it was shown that these mutations lead to a nuclear overexpression of beta-Catenin by disruption of the wingless/WNT signal pathway. Since nuclear beta-Catenin functions as a transcriptional activator of hitherto unknown tumor genes, this form of beta-Catenin is now considered a major oncoprotein in colorectal cancer. Using immunohistochemistry, we investigated the… CONTINUE READING

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