Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation

@inproceedings{Chitale2017NuclearOO,
  title={Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation},
  author={Shalaka Chitale and Holger Richly},
  booktitle={Oncotarget},
  year={2017}
}
One of the major cellular DNA repair pathways is nucleotide excision repair (NER). It is the primary pathway for repair of various DNA lesions caused by exposure to ultraviolet (UV) light, such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts. Although lesion-containing DNA associates with the nuclear matrix after UV irradiation it is still not understood how nuclear organization affects NER. Analyzing unscheduled DNA synthesis (UDS) indicates that NER preferentially occurs in… CONTINUE READING
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