Nuclear organisation of sperm remains remarkably unaffected in the presence of defective spermatogenesis

@article{Ioannou2011NuclearOO,
  title={Nuclear organisation of sperm remains remarkably unaffected in the presence of defective spermatogenesis},
  author={Dimitris Ioannou and Eric J. Meershoek and Dimitra Christopikou and Michael Richard Ellis and Alan Russell Thornhill and Darren Karl Griffin},
  journal={Chromosome Research},
  year={2011},
  volume={19},
  pages={741-753}
}
Organisation of chromosome territories in interphase nuclei has been studied in many systems and positional alterations have been associated with disease phenotypes (e.g. laminopathies, cancer) in somatic cells. Altered nuclear organisation is also reported in developmental processes such as mammalian spermatogenesis where a “chromocentre” model is proposed with the centromeres and sex chromosomes repositioning to the nuclear centre. The purpose of this study was to test the hypothesis that… CONTINUE READING
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