Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II

@article{Hofmann2006NuclearMI,
  title={Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II},
  author={W. Hofmann and Gabriela M. Vargas and R. Ramchandran and L. Stojiljkovi{\'c} and J. Goodrich and P. de Lanerolle},
  journal={Journal of Cellular Biochemistry},
  year={2006},
  volume={99}
}
The nuclear isoform of myosin, Nuclear Myosin I (NMI) is involved in transcription by RNA polymerase I. Previous experiments showing that antibodies to NMI inhibit transcription by RNA polymerase II using HeLa cell nuclear extract (NE) suggested that NMI might be a general transcription factor for RNA polymerases. In this study we used a minimal in vitro transcription system to investigate the involvement of NMI in transcription by RNA polymerase II in detail. We demonstrate that NMI co… Expand
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