Nuclear mobility and activity of FOXA1 with androgen receptor are regulated by SUMOylation.

@article{Sutinen2014NuclearMA,
  title={Nuclear mobility and activity of FOXA1 with androgen receptor are regulated by SUMOylation.},
  author={P{\"a}ivi Sutinen and Vesa Rahkama and Miia M. Rytinki and Jorma J. Palvimo},
  journal={Molecular endocrinology},
  year={2014},
  volume={28 10},
  pages={1719-28}
}
Forkhead box (FOX) protein A1 has been dubbed a pioneer transcription factor because it binds target sites in DNA, thereby displacing nucleosomes to loosen chromatin and facilitating steroid receptor DNA binding nearby. FOXA1 is an important regulator of prostate development, collaborating with androgen receptor (AR). Post-translational modifications regulating FOXA1 are thus far poorly understood. SUMOylation, post-translational modification of proteins by small ubiquitin-like modifier (SUMO… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS