Nuclear-mitochondrial cross-talk in global myocardial ischemia. A time-course analysis

  title={Nuclear-mitochondrial cross-talk in global myocardial ischemia. A time-course analysis},
  author={Jos{\'e} Mar{\'i}n-Garc{\'i}a and Shirish Damle and Bodh I. Jugdutt and Gordon W. Moe},
  journal={Molecular and Cellular Biochemistry},
Myocardial ischemia results in early and progressive damage to mitochondrial structure and function, but the molecular events leading to these changes have not been clearly established. We hypothesized that mitochondrial dysfunction and a coordinated expression of nuclear and mitochondrial genes occur in a time-dependent manner by relating the time courses of changes in parameters of mitochondrial bioenergetics after ischemia–reperfusion. Using a Langendorff rat heart model, mitochondrial… CONTINUE READING

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