Nuclear migration, nucleokinesis and lissencephaly.

  title={Nuclear migration, nucleokinesis and lissencephaly.},
  author={N. Ronald Morris and Vladimir P. Efimov and Xin Xiang},
  journal={Trends in cell biology},
  volume={8 12},
During the past 20 years, biologists have become used to finding that proteins first identified in simple, genetically manipulable eukaryotic organisms are conserved in higher eukaryotes. This article draws attention to the similarity between NUDF protein, which is required for nuclear migration in the filamentous fungus Aspergillus nidulans, and a mammalian homologue, LIS1, whose malfunction causes lissencephaly, a neuronal migration disease. The authors suggest that there might be an… CONTINUE READING

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