Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less).

@article{Nili2001NuclearMP,
  title={Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less).},
  author={Efrat Lidor Nili and Gady Cojocaru and Yael Kalma and Doron Ginsberg and Neal G. Copeland and Debra J. Gilbert and Nancy A. Jenkins and Roland Berger and Sigal Shaklai and Ninette Amariglio and Frida Brok-Simoni and Amos J. Simon and Gideon Rechavi},
  journal={Journal of cell science},
  year={2001},
  volume={114 Pt 18},
  pages={3297-307}
}
LAP2beta is an integral membrane protein of the nuclear envelope involved in chromatin and nuclear architecture. Using the yeast two-hybrid system, we have cloned a novel LAP2beta-binding protein, mGCL, which contains a BTB/POZ domain and is the mouse homologue of the Drosophila germ-cell-less (GCL) protein. In Drosophila embryos, GCL was shown to be essential for germ cell formation and was localized to the nuclear envelope. Here, we show that, in mammalian cells, GCL is co-localized with… CONTINUE READING

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