Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation.

Abstract

Matrix attachment region (MAR)-binding proteins have been implicated in the transcriptional regulation of host as well as viral genes, but their precise role in HPV-infected cervical cancer remains unclear. Here we show that HPV18 promoter contains consensus MAR element in the LCR and E6 sequences where SMAR1 binds and reinforces HPV18 E6 transcriptional… (More)
DOI: 10.1074/jbc.M114.564872

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Cite this paper

@article{Chakraborty2014NuclearMP, title={Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation.}, author={Samik Chakraborty and Kaushik Das and Shilpi Saha and Minakshi Mazumdar and Argha Manna and Sreeparna Chakraborty and Shravanti Mukherjee and Poulami Khan and Arghya Adhikary and Suchismita Mohanty and Samit Chattopadhyay and Subhash Ch Biswas and Gaurisankar Sa and Tanya Das}, journal={The Journal of biological chemistry}, year={2014}, volume={289 42}, pages={29074-85} }