Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation.

@article{Xiao2012NuclearMF,
  title={Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation.},
  author={Rui Xiao and P. T. Peter Tang and Bo Yang and Jie Tang Yan Huang and Yu Zhou and Changwei Shao and Hairi Li and Hui Sun and Yi Zhang and Xiang-Dong Fu},
  journal={Molecular cell},
  year={2012},
  volume={45 5},
  pages={656-68}
}
The nuclear matrix-associated hnRNP U/SAF-A protein has been implicated in diverse pathways from transcriptional regulation to telomere length control to X inactivation, but the precise mechanism underlying each of these processes has remained elusive. Here, we report hnRNP U as a regulator of SMN2 splicing from a custom RNAi screen. Genome-wide analysis by CLIP-seq reveals that hnRNP U binds virtually to all classes of regulatory noncoding RNAs, including all snRNAs required for splicing of… CONTINUE READING