Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci.

@article{Graham2009NuclearMB,
  title={Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci.},
  author={J. Dinny Graham and Adrienne R. Hanson and Amanda J Croft and Archa H Fox and Christine L. Clarke},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 2},
  pages={546-56}
}
The ovarian hormone progesterone is essential for normal breast development, and progesterone analogues are implicated in increasing breast cancer risk. The progesterone receptor (PR) is a transcription factor that, when ligand activated, moves rapidly into nuclear foci associated with transcriptional activity. However, the role of intranuclear trafficking signals in the focal location of PR is unknown. We have identified a mutation in PR that ablates its binding to the nuclear matrix and… CONTINUE READING