Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions.

Abstract

The immunoglobulin intragenic mu enhancer region acts as a locus control region that mediates transcriptional activation over large distances in germ line transformation assays. In transgenic mice, but not in transfected tissue culture cells, the activation of a variable region (V(H)) promoter by the mu enhancer is dependent on flanking nuclear matrix… (More)

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@article{Forrester1999NuclearMA, title={Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions.}, author={William C. Forrester and Luis Alonso Fern{\'a}ndez and Rudolf Grosschedl}, journal={Genes & development}, year={1999}, volume={13 22}, pages={3003-14} }