Nuclear magnetic resonance studies on covalent modification of amino acids thiol and amino residues by monofunctional aryl 13C-isocyanates, models of skin and respiratory sensitizers: transformation of thiocarbamates into urea adducts.

Abstract

Exposure to aryl isocyanates, intermediates in the manufacture of polyurethanes, provokes lung sensitization and asthma but also occupational allergic contact dermatitis, sensitization occurring from a single accidental exposure. The initial step in the sensitization process is believed to be the covalent binding of the -N triple bond C triple bond O group… (More)
DOI: 10.1021/tx9000539

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@article{Fleischel2009NuclearMR, title={Nuclear magnetic resonance studies on covalent modification of amino acids thiol and amino residues by monofunctional aryl 13C-isocyanates, models of skin and respiratory sensitizers: transformation of thiocarbamates into urea adducts.}, author={Olivier Fleischel and Elena Gim{\'e}nez-Arnau and J. -P. Lepoittevin}, journal={Chemical research in toxicology}, year={2009}, volume={22 6}, pages={1106-15} }