Corpus ID: 33081649

Nuclear magnetic resonance studies of drug-receptor interactions. The binding of epinphrine to isolated mouse liver cells.

@article{Fischer1969NuclearMR,
  title={Nuclear magnetic resonance studies of drug-receptor interactions. The binding of epinphrine to isolated mouse liver cells.},
  author={J. Fischer and M. Jost},
  journal={Molecular pharmacology},
  year={1969},
  volume={5 4},
  pages={
          420-4
        }
}
  • J. Fischer, M. Jost
  • Published 1969
  • Chemistry, Medicine
  • Molecular pharmacology
  • Using a technique based on the relaxation phenomenon of nuclear magnetic resonance, the interaction of a drug and its receptor site has been directly observed in an intact cellular system. The NMR spectrum of epinephrine is altered by the presence of liver cells in a manner characteristic of a binding interaction. The spectral changes permit certain conclusions to be drawn about time nature of the binding. Dichloroisoproterenol, a beta-adrenergic blocking agent, competitively inhibits the… CONTINUE READING

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