• DOI:10.1021/BI0102095
• Corpus ID: 1689325

Nuclear magnetic resonance in the era of structural genomics.

@article{Prestegard2001NuclearMR,
  title={Nuclear magnetic resonance in the era of structural genomics.},
  author={James H. Prestegard and Homayoun Valafar and John N. Glushka and Fang Tian},
  journal={Biochemistry},
  year={2001},
  volume={40 30},
  pages={
          8677-85
        }
}

• J. Prestegard, H. Valafar, +1 author F. Tian
• Published 4 July 2001
• Chemistry
• Biochemistry

Current interests in structural genomics, and the associated need for high through-put structure determination methods, offer an opportunity to examine new nuclear magnetic resonance (NMR) methodology and the impact this methodology can have on structure determination of proteins. The time required for structure determination by traditional NMR methods is currently long, but improved hardware, automation of analysis, and new sources of data such as residual dipolar couplings promise to change this. Greatly improved efficiency, coupled with an ability to characterize proteins that may not produce crystals suitable for investigation by X-ray diffraction, suggests that NMR will play an important role in structural genomics programs.