Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin

Abstract

BACKGROUND Control of the nuclear localization of specific proteins is an important mechanism for regulating many signal transduction pathways. Upon activation of the Wnt signaling pathway, beta-catenin localizes into the nucleus and interacts with TCF/LEF-1 (T-cell factor/lymphocyte enhancer factor-1) transcription factors, triggering activation of… (More)
DOI: 10.1016/S0960-9822(98)70082-X

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