Nuclear localization of vertebrate cyclin A correlates with its ability to form complexes with cdk catalytic subunits.

@article{Maridor1993NuclearLO,
  title={Nuclear localization of vertebrate cyclin A correlates with its ability to form complexes with cdk catalytic subunits.},
  author={G Maridor and Peter J. Gallant and R M Golsteyn and Erich A. Nigg},
  journal={Journal of cell science},
  year={1993},
  volume={106 ( Pt 2)},
  pages={535-44}
}
Cyclins control the activities of cyclin-dependent protein kinases (cdks) and hence play a key role in cell cycle regulation. While B-type cyclins associate with p34cdc2 to trigger entry into mitosis, progression through S phase requires cyclin A, presumably in association with p33cdk2. Vertebrate A- and B-type cyclins display strikingly distinct subcellular localizations, but the mechanisms underlying these differential distributions are unknown. Here, we have begun to study the requirements… CONTINUE READING